Summary:
I tried several different configurations with this case, and settled on reversing the fans that came with it to suck in air from the back and top vents, and exhaust out of the front vent, leaving the front door open. This makes it a bit louder, but SO much cooler. The bottom chamber has airflow from front to back as original design, creating a counter current flow which may help further cool the case frame parts inside the chambers. Finally, one HD above and one below spreads the heat, and the GPU (7800 GT) has the module on it to take cool air from outside directly to the card fan--and this seems to work. I put extra material in the connections between chamber sections and the frame screws to further dampen and solidify. Very quiet cooling solution. The wiring was challenging at times, but I got it all to my satisfaction and haven't messed with it since, although my cruft is building up, so I'll have to clean it out soon.
I haven't had problems with fans, HD cages or anything else since getting it in July, 04 and reconfigured 3 different times.

Pros:
The case is solid, well designed, quiet and cool. Looks good while doing the job. Super tweakability lets tinkerers try their own ideas for layout, airflow, wiring, etc.

Cons:
Tight wiring made for some extra time spent. Finding the right configuration for your specific components may take a few tries if you care enough to try different things. Very heavy, so don't make it your next LAN rig.